abstract：:The presence of nicotinic and muscarinic receptors suggests the occurrence of cholinergic neurotransmission in white matter; however no quantitative information exists on acetylcholine formation and breakdown in white matter. We compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and oc...

journal_title：Neurochemistry international

authors： Hassel B,Solyga V,Lossius A

更新日期：2008-12-01 00:00:00

abstract：:Age-related and aged memory deficit changes in Nestin-immunoreactive (Nestin-IR) neurons were studied following recent evidence of distinct Nestin-IR neurons within adult rat basal forebrain. Morris water maze task assessed spatial learning capacity of 3- and 24-month rats (aged-impaired and aged-unimpaired groups). N...

journal_title：Neurochemistry international

authors： Li D,Wang J,Yew DT,Lucy Forster E,Yao Z

更新日期：2008-12-01 00:00:00

abstract：:It has been shown recently that the N-terminal domain of the dopamine transporter (DAT) plays a role in several transporter functions. Here we provide evidence for a possible cellular mechanism of how the N-terminus of dopamine transporter might be removed in vivo. We isolated a recombinant N-terminal protein region o...

journal_title：Neurochemistry international

authors： Franekova V,Baliova M,Jursky F

更新日期：2008-06-01 00:00:00

abstract：:Zinc transporter 3 (ZNT3) has been shown to transport zinc ions from the cytosol into presynaptic vesicles in the mammalian brain. Several studies have stated that the zinc ion containing synaptic vesicles of zinc-enriched neurons (ZEN) are loaded with ZNT3 proteins in their membranes. This fact makes it possible to t...

journal_title：Neurochemistry international

authors： Chi ZH,Wang X,Cai JQ,Stoltenberg M,Danscher G,Wang ZY

更新日期：2008-06-01 00:00:00

abstract：:Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

journal_title：Neurochemistry international

authors： Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

更新日期：2008-05-01 00:00:00

abstract：:The evolving role of mitochondria as a target for different death-inducing noxae prompted us to investigate trimethyltin (TMT)-dependent effects on mitochondrial functionality. For this purpose, we used a homogeneous cell culture model represented by undifferentiated PC12 cells. Mitochondria isolated from PC12 cells t...

journal_title：Neurochemistry international

authors： Misiti F,Orsini F,Clementi ME,Lattanzi W,Giardina B,Michetti F

更新日期：2008-05-01 00:00:00

abstract：:Several studies have indicated a functional differentiation across the septotemporal axis of rat hippocampus. Our previous results have shown that the alpha 1 beta 2 gamma 2-GABAA receptor subtype dominates in dorsal hippocampus (DH), while the alpha 2 beta 1 gamma 2-subtype prevails in ventral hippocampus (VH). We th...

journal_title：Neurochemistry international

authors： Sarantis K,Sotiriou E,Papatheodoropoulos C,Matsokis N,Angelatou F

更新日期：2008-05-01 00:00:00

abstract：:The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

journal_title：Neurochemistry international

authors： Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

更新日期：2008-05-01 00:00:00

abstract：:We examined the intracellular delivery of Pep-1-cargo protein against transient ischemic damage in the hippocampal CA1 region in gerbils. For this study, we introduced green fluorescent protein (GFP) and constructed Pep-1-GFP protein. At 12h after Pep-1-GFP treatment, GFP fluorescence was shown in almost CA1 pyramidal...

journal_title：Neurochemistry international

authors： Cho JH,Hwang IK,Yoo KY,Kim SY,Kim DW,Kwon YG,Choi SY,Won MH

更新日期：2008-03-01 00:00:00

abstract：:Alzheimer disease (AD) is the most common form of adult dementia. Its pathological hallmarks are synaptic degeneration, deposition of amyloid plaques and neurofibrillary tangles, leading to neuronal loss. A few hypotheses have been proposed to explain AD pathogenesis. The beta-amyloid (Abeta) and hyperphosphorylated t...

journal_title：Neurochemistry international

authors： Bojarski L,Herms J,Kuznicki J

更新日期：2008-03-01 00:00:00

abstract：:Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic and by stimulating glutamatergic neurotransmission. PREGS is also a potent modulator of sigma type 1 (sigma1) receptors. It has been proposed that these actions o...

journal_title：Neurochemistry international

authors： Schumacher M,Liere P,Akwa Y,Rajkowski K,Griffiths W,Bodin K,Sjövall J,Baulieu EE

更新日期：2008-03-01 00:00:00

abstract：:In the last few years, several attempts were made for the setting up of specific methodologies aiming to evaluate steroid contents directly in nervous tissues. The main objective of these attempts was to determine accurately changes intervening in endogenous neuroactive steroid levels during pathological situations. T...

journal_title：Neurochemistry international

authors： Melcangi RC,Mensah-Nyagan AG

更新日期：2008-03-01 00:00:00

abstract：:Stroke is the third leading cause of death and the leading cause of adult disability in the industrialized nations. One of the consequences of stroke is blood-brain barrier (BBB) leakage and subsequent edema, which is one of the causes of mortality in this pathology. Aquaporin-4 (AQP4) is the most abundant water chann...

journal_title：Neurochemistry international

authors： Rite I,Machado A,Cano J,Venero JL

更新日期：2008-03-01 00:00:00

abstract：:Positron-emitting beta-adrenoceptor ligands for the CNS could allow determination of changes in beta-adrenoceptor availability after treatment of patients with norepinephrine reuptake inhibitors or tricyclic antidepressants, and differential diagnosis between multiple sclerosis and other brain disorders in an early st...

journal_title：Neurochemistry international

authors： van Waarde A,Doorduin J,de Jong JR,Dierckx RA,Elsinga PH

更新日期：2008-03-01 00:00:00

abstract：:The present study was aimed to investigate the effects of a chronic treatment with the dopamine uptake blocker nomifensine on the in vivo extracellular concentrations of dopamine, acetylcholine, glutamate and GABA in the prefrontal cortex, striatum and nucleus accumbens. Male Wistar rats received intraperitoneal (i.p....

journal_title：Neurochemistry international

authors： Hernández LF,Segovia G,Mora F

更新日期：2008-02-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that i...

journal_title：Neurochemistry international

authors： Mody I

更新日期：2008-01-01 00:00:00

abstract：:The aim of the present study was to investigate, whether dopamine D1 and/or D2 receptors are able to interfere with the ATP-induced increase of the intracellular Ca2+ concentration ([Ca2+]i) in cultured striatal neurons identified by their morphological characteristics and their [Ca2+]i transients in response to a hig...

journal_title：Neurochemistry international

authors： Rubini P,Engelhardt J,Wirkner K,Illes P

更新日期：2008-01-01 00:00:00

abstract：:On the basis of abnormal neuropsychological behavior in the open-field test after 2-week zinc deprivation, neurochemical response was examined in young mice fed a zinc-deficient diet for 2 weeks. Serum corticosterone concentration was markedly higher in zinc-deficient mice than in the control mice. Basal signals of in...

journal_title：Neurochemistry international

authors： Takeda A,Yamada K,Tamano H,Fuke S,Kawamura M,Oku N

更新日期：2008-01-01 00:00:00

abstract：:AMPA receptors are fast ligand-gated members of glutamate receptors in neuronal and many types of non-neuronal cells. The heterotetramer complexes are assembled from four subunits (GluR1-4) in region-, development- and function-selective patterns. Each subunit contains three extracellular domains (a large amino termin...

journal_title：Neurochemistry international

authors： Szénási G,Vegh M,Szabo G,Kertesz S,Kapus G,Albert M,Greff Z,Ling I,Barkoczy J,Simig G,Spedding M,Harsing LG Jr

更新日期：2008-01-01 00:00:00

abstract：:The discovery of nonsynaptic communication in the 1960s and 1970s was an important milestone in investigating the function of the nervous system, and it revolutionized our view about information transmission between neurons. In addition, nonsynaptic communication has a practical importance not only within the nervous ...

journal_title：Neurochemistry international

authors： Selmeczy Z,Vizi ES,Csóka B,Pacher P,Haskó G

更新日期：2008-01-01 00:00:00

abstract：:While studies with [(3)H]D-aspartate ([(3)H]d-Asp) illustrate specific interactions with excitatory amino acid transporters (EAATs), new insights into the pharmacological characteristics and localization of specific EAAT subtypes depend upon the availability of novel ligands. One such ligand is [(3)H]-(2S,4R)-4-methyl...

journal_title：Neurochemistry international

authors： Apricò K,Beart PM,Crawford D,O'shea RD

更新日期：2007-12-01 00:00:00

abstract：:Oxidative stress-induced neuronal death due to hydrogen peroxide overload plays a critical role in the pathogenesis of numerous neurological diseases. Insulin-like growth factor-1 (IGF-1) is important in maintaining neuronal survival, proliferation, and differentiation in the central nervous system. We now report that...

journal_title：Neurochemistry international

authors： Zhong J,Lee WH

更新日期：2007-11-01 00:00:00

abstract：:There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO(-)), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to co...

journal_title：Neurochemistry international

authors： Sáenz DA,Bari SE,Salido E,Chianelli M,Rosenstein RE

更新日期：2007-11-01 00:00:00

abstract：:G protein-coupled receptors are cell surface receptors that mediate the effects of extracellular signals in the endocrine/paracrine and sensory systems. Experimental evidence is accumulating, which suggest that these receptors form dimers or higher order oligomers. The functional relevance of G protein-coupled recepto...

journal_title：Neurochemistry international

authors： Karip E,Turu G,Süpeki K,Szidonya L,Hunyady L

更新日期：2007-10-01 00:00:00

abstract：:The present study confirmed our previous assumption on the crucial role of central alpha2B-like adrenoceptor subtype in gastric mucosal defense. It was found that beside clonidine, rilmenidine, an alpha2/imidazoline receptor agonist and ST-91, an alpha2B-adrenoceptor preferring agonist inhibited the mucosal lesions in...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Shujaa N,Minorics R,Falkay G,Mátyus P

更新日期：2007-10-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

journal_title：Neurochemistry international

authors： Jiang H,Song N,Wang J,Ren LY,Xie JX

更新日期：2007-07-01 00:00:00

abstract：:Two signaling pathways, phosphoinositide 3-kinase (PI-3k)/Akt and Ras/MAPK, are major effectors triggered by nerve growth factor (NGF). Rac1, Cdc42 and GSK-3beta are reported to be targets of PI-3k in the signal transduction for neurite outgrowth. Immediately after NGF was added, broad ruffles were observed temporaril...

journal_title：Neurochemistry international

authors： Jin E,Nosaka K,Sano M

更新日期：2007-07-01 00:00:00

abstract：:Na+-dependent uptake of excitatory neurotransmitter glutamate in astrocytes increases cell energy demands primarily due to the elevated ATP consumption by glutamine synthetase and Na+, K+-ATPase. The major pool of GLAST/EAAT1, the only glutamate transporter subtype expressed by human fetal astrocytes in undifferentiat...

journal_title：Neurochemistry international

authors： Gegelashvili M,Rodriguez-Kern A,Sung L,Shimamoto K,Gegelashvili G

更新日期：2007-06-01 00:00:00

abstract：:In this review, we summarize the role of hyperglycemia during cerebral ischemia. Hyperglycemia occurring during experimental and clinical stroke has been associated with increased cerebral damage. Increased oxidative stress resulting from hyperglycemia is believed to contribute to the exacerbated damage. More specific...

journal_title：Neurochemistry international

authors： Bémeur C,Ste-Marie L,Montgomery J

更新日期：2007-06-01 00:00:00

abstract：:Glutamate neurotoxicity is implicated in most neurodegenerative diseases, and in the present study the long-term effects of the glutamate agonist kainic acid (KA) on cerebellar neurons are investigated. Primary cell cultures, mainly consisting of glutamatergic granule neurons, were cultured in medium containing 0.05 o...

journal_title：Neurochemistry international

authors： Olstad E,Qu H,Sonnewald U

更新日期：2007-06-01 00:00:00

abstract：:We showed that dextromethorphan (DM) provides neuroprotective/anticonvulsant effects and that DM and its major metabolite, dextrorphan, have a high-affinity for sigma(1) receptors, but a low affinity for sigma(2) receptors. In addition, we found that DM has a higher affinity than DX for sigma(1) sites, whereas DX has ...

journal_title：Neurochemistry international

authors： Shin EJ,Nah SY,Chae JS,Bing G,Shin SW,Yen TP,Baek IH,Kim WK,Maurice T,Nabeshima T,Kim HC

更新日期：2007-05-01 00:00:00

abstract：:A noticeable loss of cardiolipin, a significant accumulation of fluorescent products of lipid peroxidation and an increased ability to produce reactive oxygen species in vitro are characteristics of aged rat brain mitochondria, as has been demonstrated in this study. In contrast mitochondrial electron transport chain ...

journal_title：Neurochemistry international

authors： Sen T,Sen N,Jana S,Khan FH,Chatterjee U,Chakrabarti S

更新日期：2007-04-01 00:00:00

abstract：:Alteration in the lysosomal system (LS) may represent a central mechanism in neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death in catecholaminergic cells. The LS and caspases participate in apoptosis, although the mechanism(s) that is involved is not completely understood. Here, we ...

journal_title：Neurochemistry international

authors： Lee DC,Womble TA,Mason CW,Jackson IM,Lamango NS,Severs WB,Palm DE

更新日期：2007-03-01 00:00:00

abstract：:Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central muscle relaxant activity as well. Selective serotonin reuptake inhibitors are also applied in the treatment of pain syndromes. Here, we investigate the pharmacody...

journal_title：Neurochemistry international

authors： Thán M,Kocsis P,Tihanyi K,Fodor L,Farkas B,Kovács G,Kis-Varga A,Szombathelyi Z,Tarnawa I

更新日期：2007-03-01 00:00:00

abstract：:Individual analysis of synaptic terminals calcium responses, induced by dinucleotides pentaphosphate, Ap(5)A or Gp(5)G, demonstrates the presence of two main groups considering the concentration required for stimulation. The first group corresponds to those responding to Ap(5)A or Gp(5)G at nanomolar concentration, re...

journal_title：Neurochemistry international

authors： Gómez-Villafuertes R,Sánchez-Nogueiro J,Marín-García P,Miras-Portugal MT

更新日期：2007-03-01 00:00:00

abstract：:Ex vivo(1)H NMR spectroscopy was used to measure changes in the concentrations of cerebral metabolites in the prefrontal cortex (PFC) and hippocampus of rats subjected to repeated morphine treatment known to cause tolerance/dependence. The results show that repeated morphine exposure induces significant changes in the...

journal_title：Neurochemistry international

authors： Gao H,Xiang Y,Sun N,Zhu H,Wang Y,Liu M,Ma Y,Lei H

更新日期：2007-01-01 00:00:00

abstract：:Dopamine is the main catecholamine found in the chick retina whereas norepinephrine is only found in trace amounts. We compared the effectiveness of dopamine and norepinephrine in promoting cyclic AMP accumulation in retinas at embryonic day 13 (E13) and from post-hatched chicken (P15). Dopamine (EC(50)=10microM) and ...

journal_title：Neurochemistry international

authors： Kubrusly RC,Ventura AL,de Melo Reis RA,Serra GC,Yamasaki EN,Gardino PF,de Mello MC,de Mello FG

更新日期：2007-01-01 00:00:00

abstract：:Poly(ADP-ribose)polymerase-1 (PARP-1) overactivation is a key event in neurodegeneration but the underlying molecular mechanisms wait to be unequivocally identified. Energy failure, transcriptional derangement and deadly nucleus-mitochondria cross-talk have been proposed as mechanisms responsible for PARP-1 neurotoxic...

journal_title：Neurochemistry international

authors： Fossati S,Cipriani G,Moroni F,Chiarugi A

更新日期：2007-01-01 00:00:00

abstract：:Axonal transport of tripeptidyl peptidase II, a putative cholecystokinin inactivating serine peptidase, was examined in the proximal, middle, and distal segments of rat sciatic nerves using a double ligation technique. Enzyme activity significantly increased not only in the proximal segment but also in the distal segm...

journal_title：Neurochemistry international

authors： Chikuma T,Shimizu M,Tsuchiya Y,Kato T,Hojo H

更新日期：2007-01-01 00:00:00

abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

journal_title：Neurochemistry international

authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

更新日期：2006-12-01 00:00:00